1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins
  4. ICOS CD278/ICOS
  5. ICOS 蛋白, Rhesus macaque (HEK293,Fc)

ICOS 蛋白, Rhesus macaque (HEK293,Fc)

目录号: HY-P70187
产品使用指南

ICOS 蛋白在增强所有基本 T 细胞对外源抗原反应方面发挥着关键作用。它促进细胞增殖、淋巴因子分泌和细胞间相互作用分子的上调,并促进有效的 B 细胞抗体分泌。ICOS 蛋白, Rhesus macaque (HEK293,Fc) 是重组的 ICOS 蛋白,由 HEK293 表达,带有 C-hFc 标签。ICOS 蛋白, Rhesus macaque (HEK293,Fc) 全长 121 个氨基酸,分子量为 50-60 kDa。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus macaque (HEK293,Fc) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICOS Protein, Rhesus macaque (HEK293,Fc) is 121 a.a., with molecular weight of 50-60 kDa.

研究背景

ICOS蛋白在增强T细胞对外来抗原的所有基本反应中发挥着至关重要的作用,包括促进细胞增殖、淋巴因子的分泌、参与细胞间相互作用的分子的上调以及促进B-抗体分泌的有效帮助。细胞。它对于促进 T 细胞和 B 细胞之间的有效通讯以及对 T 细胞依赖性抗原的正常抗体反应是必不可少的。虽然它不会增加白细胞介素 2 的产生,但它具有超级诱导白细胞介素 10 合成的能力。此外,ICOS 还可防止预激活 T 细胞的凋亡,并在 CD40 介导的免疫球蛋白同种型类型转换中发挥关键作用。它以通过二硫键连接的同二聚体形式存在。

种属

Rhesus Macaque

表达系统

HEK293

标签

C-hFc

蛋白编号

H9Z062 (G20-K140)

基因 ID

705788  [NCBI]

蛋白结构
N-term
ICOS (G20-K140)
Accession # H9Z062
hFc
C-term
同用名
rRhInducible T-cell costimulator/ICOS, Fc ; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS
氨基酸序列

GEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDRSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLK

分子量

50-60 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ICOS Protein, Rhesus macaque (HEK293,Fc)
目录号:
HY-P70187
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