1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-alpha
  5. IFN-alpha 14
  6. IFN-alpha 14/IFNA14 蛋白, Human (His-SUMO)

IFN-alpha 14/IFNA14 蛋白, Human (His-SUMO)

目录号: HY-P72243
COA 产品使用指南

IFN-alpha 14 (IFNA14) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 14/IFNA14 蛋白 (His-SUMO) 含有 166 个氨基酸 (C24-D189),由 E. coli 细胞产生并带有 N 端 His 和 SUMO 融合标签。

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20 μg ¥2150 In-stock
50 μg ¥4730 In-stock
100 μg   询价  

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描述

IFN-alpha 14 (IFNA14), belongs to type I interferon family, is produced by macrophages with antiviral activities[1]. IFN-alpha 14/IFNA14 Protein, Human (His-SUMO) contains 166 a.a. (C24-D189), produced in E. coli cells with a N-terminal His-SUMO tag.

研究背景

IFN-α 14(IFNA14;IFN-α14)属于 α/β 干扰素 (IFN) 家族,由巨噬细胞产生,具有抗病毒活性[1]。干扰素(IFN)最初被认为是一种在体外“干扰”病毒复制的物质。IFN-α/β及相关分子被归类为I型干扰素,其他两类分别为II型干扰素(IFN-γ)和III型干扰素(IFN-λ)[2]
干扰素刺激两种酶的产生:蛋白激酶和寡腺苷酸合成酶。干扰素 α (IFNa) 在多种癌症中显示出显着的生物活性,特别是血液系统恶性肿瘤,例如毛细胞白血病和慢性粒细胞白血病[3]
IFN-α 14 参与 JAK/STAT 信号传导途径,被认为是减少 CTLA4 和 FOXP3 的有效调节剂。因此,调节性T细胞(Treg)作为调节外周自身反应性T淋巴细胞的关键细胞,IFNα-14调节Treg功能状态并破坏Treg[4]的稳定性。
IFN-α14是一个新基因在未感染小鼠的组织中发现,也发现缺乏 N-糖基化,并且其表达是针对病毒感染而诱导的,与 IFN-α 13[5]

体外研究
(In Vitro)

IFN-alpha 14 (10 pM-10 μM; 24-26 h) results signifcant reduction of both CTLA4 and FOXP3 gene expression in regulatory T cells (Tregs) without affecting cell viability[4].

种属

Human

表达系统

E. coli

标签

N-6*His;N-SUMO

蛋白编号

P01570 (C24-D189)

基因 ID
蛋白结构
N-term
6*His-SUMO
IFNA14 (C24-D189)
Accession # P01570
C-term
中文名
重组人 IFN-alpha 14/IFNA14 蛋白 (His-SUMO)
同用名
IFN-alpha14; IFN14_HUMAN; IFNA14; Interferon alpha 14; Interferon alpha H; Interferon alpha-14; Interferon alpha-H; Interferon lambda-2-H; Interferon lambda2H ; LeIF H; LeIFH; MGC125756; MGC125757
氨基酸序列

CNLSQTHSLNNRRTLMLMAQMRRISPFSCLKDRHDFEFPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDETLLEKFYIELFQQMNDLEACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD

分子量

Approximately 35.7 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

IFN-alpha 14/IFNA14 Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IFN-alpha 14/IFNA14 Protein, Human (His-SUMO)
目录号:
HY-P72243
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