1. 重组蛋白
  2. Cytokines and Growth Factors
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  4. IFN-beta
  5. IFN-beta 蛋白, Human (HEK293, Fc)

IFN-beta 蛋白, Human (HEK293, Fc)

目录号: HY-P73129
COA 产品使用指南

IFN-β(干扰素-β)是一种关键的 I 型干扰素细胞因子,可协调对感染、肿瘤和炎症的先天免疫反应。IFN-β 与高亲和力 (IFNAR2) 和低亲和力 (IFNAR1) 异二聚体受体结合,激活 Jak-STAT 信号传导,并调节干扰素调节基因。IFN-beta 蛋白, Human (HEK293, Fc) 是重组的 IFN-β 蛋白,由 HEK293 表达,带有 C-hFc 标签。IFN-beta 蛋白, Human (HEK293, Fc) 全长 187 个氨基酸,分子量约为 ~52 kDa。

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2 μg ¥580 In-stock
10 μg ¥1600 In-stock
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100 μg ¥6400 In-stock
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描述

IFN-β (interferon-β) is a key type I interferon cytokine that coordinates the innate immune response to infection, tumors, and inflammation. IFN-β binds to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptors, activates Jak-STAT signaling, and modulates interferon-regulated genes. IFN-beta Protein, Human (HEK293, Fc) is the recombinant human-derived IFN-beta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IFN-beta Protein, Human (HEK293, Fc) is 187 a.a., with molecular weight of ~52 kDa.

研究背景

IFN-β(干扰素-β)是一种关键的 I 型干扰素细胞因子,在协调针对各种挑战(包括感染、肿瘤发展和炎症刺激)的先天免疫反应中发挥着关键作用。IFN-β 通过高亲和力 (IFNAR2) 和低亲和力 (IFNAR1) 异二聚体受体发挥作用,触发经典的 Jak-STAT 信号通路,导致干扰素调节基因的转录激活或抑制。这些基因反过来编码对干扰素反应至关重要的效应子,包括抗病毒蛋白、细胞增殖和分化的调节因子以及免疫调节蛋白。虽然主要通过 IFNAR1-IFNAR2 异二聚体受体发出信号,但 IFN-β 还通过单独与 IFNAR1 一起发挥作用并独立于 Jak-STAT 途径发挥作用,从而表现出多功能性。其多方面作用涵盖抗病毒和抗菌活性、调节 B 细胞发育、骨髓生成和脂多糖诱导的肿瘤坏死因子的产生。在神经元稳态领域,IFN-β作为守护者出现,通过促进神经元自噬和α-突触核蛋白清除来调节多巴胺更新并保护多巴胺能神经元,从而避免多巴胺能神经元损失。值得注意的是,IFN-β 的效力超过了干扰素-α (IFN-α),特别是在诱导细胞凋亡和抗增殖途径方面,这对控制肿瘤细胞生长至关重要。IFN-β 作为单体存在,在多种生理反应和免疫调节中发挥着多才多艺和强大的作用。

生物活性

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV) and the ED50 is 0.06-0.8 ng/mL.

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

P01574 (M1-N187)

基因 ID
蛋白结构
N-term
IFN-beta (M1-N187)
Accession # P01574
hFc
C-term
同用名
Interferon beta; IFN-beta; IFNB1; IFB; IFNB
分子量

Approximately 52 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

溶液.

组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料

IFN-beta Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IFN-beta Protein, Human (HEK293, Fc)
目录号:
HY-P73129
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