IGFBP-5 蛋白, Human (Biotinylated, HEK293, His-Avi)

The IGFBP-5 protein regulates insulin-like growth factor (IGF) and extends its lifespan. It can inhibit or stimulate the growth-promoting effect of IGF, showing its dual regulatory function. IGFBP-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGFBP-5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of IGFBP-5 Protein, Human (Biotinylated, HEK293, His-Avi) is 252 a.a., with molecular weight of 32-45 kDa.

IGFBP-5 蛋白通过延长胰岛素样生长因子 (IGF) 的半衰期，在调节其活性方面发挥着至关重要的作用。在细胞培养中，IGFBP-5 已被证明能够抑制或刺激 IGF 的生长促进作用。这种双重调节功能强调了 IGFBP-5 对细胞过程影响的复杂性。重要的是，IGFBP-5 通过调节 IGF 与其细胞表面受体之间的相互作用来实现这些效果，从而微调与生长和发育相关的信号通路。IGFBP-5 和 IGF 之间错综复杂的相互作用凸显了控制细胞对生长因子反应的微妙控制机制，为了解 IGFBP-5 在细胞生长和增殖调节中的多方面作用提供了见解。

Human

HEK293

C-Avi;C-6*His

P24593 (L21-E272)

3488  [NCBI]

LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE

32-45 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.