IGFBP-1 蛋白, Mouse (SUMO, His)

The IGFBP-1 protein is an insulin-like growth factor binding protein that extends the half-life of IGF and modulates its growth-promoting effects in cell cultures, thereby inhibiting or stimulating these responses. Crucially, it alters the interaction between IGF and its cell surface receptors and promotes cell migration. IGFBP-1 Protein, Mouse (SUMO, His) is the recombinant mouse-derived IGFBP-1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of IGFBP-1 Protein, Mouse (SUMO, His) is 247 a.a., with molecular weight of ~43 kDa.

IGFBP-1 是一种胰岛素样生长因子结合蛋白，通过延长 IGF 的半衰期并调节其对细胞培养物的生长促进作用（抑制或刺激这些作用）来促进 IGF 的调节。这种蛋白质在改变 IGF 与其细胞表面受体之间的相互作用方面发挥着至关重要的作用。此外，IGFBP-1 表现出促进细胞迁移的能力，表明它参与生长调节以外的细胞过程。值得注意的是，它对 IGF1 和 IGF2 具有相同的结合亲和力，突出了其在调节胰岛素样生长因子的生物活性中的多功能作用。

Mouse

E. coli

N-6*His;N-SUMO

P47876 (A26-N272)

16006  [NCBI]

APQPWHCAPCTAERLGLCPPVPASCPEISRPAGCGCCPTCALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREIADLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVHN

Approximately 43 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl,0.5 M NaCI, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.