IgG2 Fc 蛋白, Human (HEK293)

The IgG2 Fc protein is the constant region of the immunoglobulin heavy chain and acts as an antigen receptor, triggering the expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG2 Fc Protein, Human (HEK293) is the recombinant human-derived IgG2 Fc protein, expressed by HEK293, with tag free.

免疫球蛋白重链的恒定区（称为抗体）包含由 B 淋巴细胞合成的膜结合或分泌糖蛋白。在体液免疫的识别阶段，这些膜结合的免疫球蛋白充当受体，在结合特定抗原后触发B淋巴细胞的克隆扩增和分化为分泌免疫球蛋白的浆细胞。由分泌的免疫球蛋白介导的效应阶段导致结合抗原的消除。抗原结合位点由一条重链的可变结构域及其相关轻链的可变结构域形成，导致每种免疫球蛋白拥有两个对特定抗原具有显着亲和力的抗原结合位点。可变结构域经历 V-(D)-J 重排和随后的体细胞超突变，促进暴露和选择后特定抗原的亲和力成熟。免疫球蛋白由两条相同的重链和两条相同的轻链组成，通过二硫键互连。

Human

HEK293

Tag Free

P01859-1 (E99-L326)

/

Partial

ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDISVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Approximately 30-33 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH7.4 with trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.