IL-11R alpha 蛋白, Canine (HEK293, Fc)

IL-11R alpha (IL-11RA) is the IL-11 receptor subunit α and also acts as an agonist of IL-11. IL-11R alpha binds to IL6ST/gp130 on cell surfaces and induces signal transduction^[1]. IL-11R alpha activates Jak family of tyrosine kinases, JAK1, JAK2, and TYK2^[3]. IL-11R alpha induces proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells^[4]. IL-11R alpha plays an important role in the progression and the differentiation of human gastric carcinomas^[5]. IL-11R alpha Protein, Canine (HEK293, Fc) is a recombinant protein with a Fc label that consists of 363 amino acids (M1-L363) and is produced by HEK293 cells.

IL-11RA 在基质细胞上高表达，包括成纤维细胞、平滑肌细胞、脂肪细胞和肝/胰腺星状细胞或周细胞，也在上皮/极化细胞上高表达，例如肝细胞、肺泡上皮细胞和肾小管上皮细胞^[1]。
人IL-11R α蛋白的氨基酸序列与小鼠和大鼠IL-11R α蛋白的同源性较低。
IL-11R α是IL-11的受体，是IL-11触发的信号机制-11 通过 IL-11R α 介导。IL-11R α可以结合IL-11，然后复合物吸引gp130导致信号转导。此外，IL11RA 已被证明可以激活 IL-11 介导的 gp130 信号传导，但不能激活可溶性 IL-11 受体的天然形式。IL-11 与 IL11RA 的结合触发异二聚化、酪氨酸磷酸化和 gp130 的激活。激活的 IL11RA–gp130 受体复合物进一步激活 Jak 酪氨酸激酶家族 JAK1、JAK2 和 TYK2^[3]。
IL-11R α 在体外也可充当 IL-11 激动剂^[3]。IL-11R α 诱导成骨祖细胞或其他间充质细胞的增殖和/或分化^[4][5]。

Canine

HEK293

C-hFc

XP_538710 (M1-L363)

481588  [NCBI]

Approximately 64 kDa.

Greater than 80% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.

• [1]. Schafer S, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 Dec 7;552(7683):110-115.

  [2]. Cook SA, et al. Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation. Annu Rev Med. 2020 Jan 27;71:263-276.  [Content Brief]

  [3]. Balakrishnan L, et al. IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. Cell Commun Adhes. 2013 Aug;20(3-4):81-6.  [Content Brief]

  [4]. Dams-Kozlowska H, et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC Biotechnol. 2012 Mar 21;12:8.  [Content Brief]

  [5]. Nakayama T, et al. Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. Int J Oncol. 2007 Apr;30(4):825-33.  [Content Brief]