IL-13R alpha 1 蛋白, Cynomolgus (HEK293, His)

The IL-13R α 1 protein binds to IL13 with low affinity and, when combined with IL4RA, forms a functional IL13 receptor. It also functions together with IL4RA as an alternative accessory protein for IL4 signaling. IL-13R alpha 1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-13R alpha 1 Protein, Cynomolgus (HEK293, His) is 317 a.a., with molecular weight of ~37.9 KDa.

IL-13R α1 蛋白与白细胞介素 13 (IL13) 表现出低亲和力结合，当与 IL4RA 结合时，形成 IL13 的功能性受体。此外，IL-13R α 1 与 IL4RA 一起作为白细胞介素 4 (IL4) 信号转导的替代辅助蛋白。虽然它不能取代 IL2RG 增强白细胞介素 2 (IL2) 结合活性的功能，但 IL-13R α 1 在介导 IL4 和 IL13 反应中发挥着至关重要的作用。IL-13 受体复合物包含 IL4R、IL13RA1 和潜在的其他成分，这说明了其分子结构的复杂性。此外，IL-13R α 1 与 TRAF3IP1 和 IL4 相互作用，有助于其参与多种信号传导途径，并强调其作为 IL-13 受体系统组成部分的重要性。

Measured by its binding ability in a functional ELISA. When Recombinant Cynomolgus IL-13R alpha 1 at 4 µg/mL (100 µL/well) can bind Recombinant human IL-13. The ED₅₀ for this effect is 42.49 ng/mL.

Cynomolgus

HEK293

C-6*His

XP_005594500 (A25-T341)

102135058  [NCBI]

APTETQPPVTNLSVSVENLCTVIWTWNPPEGASPNCSLWYFSHFGDKQDKKLAPETRRSKEVPLNEKICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMQCSWLPGRNTSPDTNYTLYYWHRSLEKIRQCEEIYKEGQYFGCSFDLTKVKDSSFEQHSVQIMVKDYAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNGDLHVQWENPQNFISRCLFYEVEVNNSQTETHNVFSVQEAKCQNPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST

Approximately 50-70 kDa due to the glycosylation

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.