1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-19
  5. IL-19 蛋白, Human

IL-19 蛋白, Human

目录号: HY-P7212
COA 产品使用指南

IL-19 蛋白, Human是白细胞介素-10家族的成员。 IL-19 Protein的生物学功能和临床意义仍待研究。

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规格 价格 是否有货 数量
10 μg ¥2100 In-stock
50 μg ¥6200 In-stock
100 μg   询价  

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  • 参考文献

描述

IL-19 Protein, Human is a member of the Interleukin-10 family. The biological functions and clinical implications of Interleukin-19 is still undefined.

研究背景

IL-19IL-10 具有 21% 的氨基酸同一性。IL-19的外显子/内含子结构与人IL-10基因的外显子/内含子结构相似,在IL-19 cDNA的编码区内包含五个外显子和四个内含子。IL-19 不结合经典 IL-10 受体复合物或通过其发出信号[1]IL-19 通过由 IL-20Ra 和 IL20Rb 组成的受体复合物发挥作用,IL-20IL-24 也利用该受体复合物。IL19 已被证明可以增强 T 细胞中 Th2 细胞因子的产生,并且在哮喘患者中升高。此外,它还诱导单核细胞中 IL-6、IL-8 和 IL-10 的表达。此外,它还与一系列疾病和紊乱有关,包括衰老、I 型糖尿病、内毒素性休克、牙周病、血管疾病和类风湿性关节炎[2]

生物活性

The ED50 is <1.5 ng/mL as measured by murine BaF3 pro-B cells, corresponding to a specific activity of >6.7 × 105 units/mg.

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q9UHD0 (L25-A177)

基因 ID
蛋白结构
N-term
IL-19 (L25-A177)
Accession # Q9UHD0
C-term
中文名
重组人白细胞介素-19
同用名
rHuIL-19; Melanoma differentiation association like protein; ZMDA1
氨基酸序列

LRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMSSA

分子量

Approximately 17.9 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

IL-19 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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