1. 重组蛋白
  2. Cytokines and Growth Factors Biotinylated Proteins
  3. Interleukin & Receptors
  4. IL-1R
  5. IL-1 Receptor Accessory Proteins
  6. IL-1RAcP/IL-1 R3 蛋白, Human (HEK293, His-Avi)

IL-1RAcP/IL-1 R3 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78463
产品使用指南

IL-1RAcP 分别是 IL-36、IL-1 和 IL-33 信号系统中 IL1RL2、IL1R1 和 IL1RL1 的辅助受体。IL-1RAcP 是IL-1 受体的重要组成部分,在炎症过程中发挥重要作用。IL-1RAcP/IL-1 R3 蛋白, Human (HEK293, His-Avi) 是一种重组人 IL-1RAcP 蛋白,在 HEK293 细胞中表达,C 端带有 His 和Avi 标签,由 339 个氨基酸组成 (S21-E359)。

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100 μg   询价  

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描述

IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an essential component of the IL-1 receptor and plays an essential role in the inflammatory process[1][2]. IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His-Avi) is a recombinant human IL-1RAcP protein with a His and an Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 339 amino acids (S21-E359).

研究背景

Interleukin-1 receptor accessory protein (IL-1RAcP), also known as IL-1 R3, belongs to the immunoglobulin (Ig) superfamily. IL-1RAcP can be detected in liver, skin, placenta, thymus and lung.
The human IL-1RAcP protein shares 89.12% a.a sequence identity with mouse and 88.95% identity with rat.
IL-1RAcP contains three Ig-like domains and a cytoplasmic domain named Toll/IL-1 receptor (TIR) (position: 403-546 a.a), which has been implicated in signal transduction. IL-1RAcP also contains a single transmembrane region. IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, links events at the plasma membrane level to downstream signaling pathways, mediates interleukin-1-dependent transcription factor activation and gene expression.
IL-1RAcP plays an essential role in the inflammatory process and can be used for the research of obesity, diabetics, endometriosis, atherosclerosis, and so on[1][2][3].

生物活性

Immobilized Human IL-1R3 at 0.5 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-IL-1R3 Antibody hFc with the EC50 of 14.0 ng/mL determined by ELISA.

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

Q9NPH3 (S21-E359)

中文名
重组人 IL-1RAcP/IL-1 R3 蛋白 (HEK293, His-Avi)
同用名
IL1RAP; C3orf13; IL-1 R3; IL-1 RAcP
分子量

52-70 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

性状

Lyophilized powder.

组分

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5 % trehalose is added as protectant before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献
  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His-Avi)
目录号:
HY-P78463
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