IL-21R 蛋白, Mouse (HEK293, Fc)

The IL-21R protein is specifically designed for IL-21 and forms a heterodimeric complex with the common γ subunit, which is critical for signal transduction. This receptor complex promotes interaction with Janus kinase 1 (JAK1), initiating downstream signaling events in response to interleukin-21. IL-21R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-21R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-21R Protein, Mouse (HEK293, Fc) is 217 a.a., with molecular weight of 63-75 kDa.

IL-21R 蛋白作为专门为白细胞介素 21 设计的受体发挥作用，与常见的 γ 亚基形成异二聚体复合物。这种受体复合物对于转导白细胞介素 21 启动的信号至关重要，使细胞能够对该细胞因子做出反应。IL-21R 异二聚体结构促进其与 Janus 激酶 1 (JAK1) 的相互作用，在响应白细胞介素 21 结合而启动下游信号传导事件中发挥关键作用。IL-21R 与常见 γ 亚基的结合及其与 JAK1 的相互作用共同促进白细胞介素 21 介导的信号转导，从而影响各种细胞过程和免疫反应。

Measured by its binding ability in a functional ELISA. Immobilized Mouse IL-21, at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-21R protein. The ED₅₀ for this effect is 25.10 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Mouse IL-21, at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-21R protein. The ED₅₀ for this effect is 25.10 ng/mL.

Mouse

HEK293

C-hFc

Q9JHX3 (C20-P236)

60504  [NCBI]

CLDLTCYTDYLWTITCVLETRSPNPSILSLTWQDEYEELQDQETFCSLHRSGHNTTHIWYTCHMRLSQFLSDEVFIVNVTDQSGNNSQECGSFVLAESIKPAPPLNVTVAFSGRYDISWDSAYDEPSNYVLRGKLQYELQYRNLRDPYAVRPVTKLISVDSRNVSLLPEEFHKDSSYQLQVRAAPQPGTSFRGTWSEWSDPVIFQTQAGEPEAGWDP

63-75 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4 (Normally trehalose is added as protectant before lyophilization. ) or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.