IL-21R 蛋白, Rat (HEK293, His)

IL-21R Protein, a receptor for interleukin-21, is a type I cytokine receptor. It forms a heterodimer with the common gamma subunit and associates with Janus kinase 1 (JAK1). These interactions are pivotal for transducing the cellular responses initiated by interleukin-21, regulating immune processes and inflammatory pathways. IL-21R Protein, Rat (HEK293, His) is the recombinant rat-derived IL-21R protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-21R Protein, Rat (HEK293, His) is 217 a.a., with molecular weight of 32-50 kDa.

白细胞介素 21 受体 (IL-21R) 是白细胞介素21的受体，是I型细胞因子受体。它与常见的 γ 亚基形成异二聚体，并与 Janus 激酶 1 (JAK1) 结合。通过这种相互作用，受体促进由白细胞介素 21 (一种具有多种免疫调节功能的细胞因子) 引发的信号级联反应。IL-21R 异二聚体的形成及其与 JAK1 的关联是转导白细胞介素 21 触发的细胞反应的关键步骤，有助于免疫过程和炎症途径的调节。IL-21R在血液恶性肿瘤中高表达，并增强滤泡性淋巴瘤的侵袭性。IL-21R 通过激活 JAK/STAT 信号通路导致白血病和大细胞淋巴瘤的发病机制。IL-21R的敲低显著抑制了GC细胞的增殖和侵袭，并且进一步验证了IL-21R的表达受到miR-125a-3p（miR-125a）的负向调节。此外，它还通过抑制 Wnt/β-catenin 信号传导和 PD-L1 表达来减少 NSCLC 细胞的生长和侵袭^[1][2]。

Measured by its binding ability in a functional ELISA. Immobilized Human IL-21 at 5 μg/mL (100 μL/well) can bind Rat IL-21R, the ED₅₀ for this effect is 28.13 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Human IL-21 at 5 μg/mL (100 μL/well) can bind Rat IL-21R, the ED₅₀ for this effect is 28.13 ng/mL.

Rat

HEK293

C-His

Q5EBB1 (C20-P236)

308977  [NCBI]

CLDLTCYTDYLWTITCVLETWSPNPSILSLTWQDEYEELQDKETSCSLHASGHNTTHMWYTCHMRLSQFMSDDVFTVNMMDQSSNSSQECGSFVLAESIKPAPPLNVTVTFSGRYDISWDSIYEEPSNYVLRGKLQYELQYRNLRDPYAVRPVTKLISVDSRNISLLPQEFQKDSSYQLQVRAAPQPGTSFRGTWSEWSDPIIFQTQAEEPEAGWDP

32-50 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.