1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-22BP
  5. IL-22BP/IL-22RA2 蛋白, Human (210a.a, HEK293, His)

IL-22BP/IL-22RA2 蛋白, Human (210a.a, HEK293, His)

目录号: HY-P72557
COA 产品使用指南

IL-22BP/IL-22RA2 蛋白(特别是异构体 2)充当 IL22 受体和拮抗剂,通过阻止其与体外功能性 IL-22R 复合物相互作用来抑制 IL22 活性。这种调节作用表明其在调节炎症反应方面的潜力。相比之下,异构体 1 参与与成功怀孕相关的过程,表明在生殖生理学中具有独特的作用。 IL-22BP 亚型的双重作用凸显了它们在影响炎症途径和生殖结果方面的多功能性。IL-22BP/IL-22RA2 蛋白, Human (210a.a, HEK293, His) 是重组的 IL-22BP/IL-22RA2 蛋白,由 HEK293 表达,带有 C-6*His 标签。IL-22BP/IL-22RA2 蛋白, Human (210a.a, HEK293, His) 全长 210 个氨基酸,分子量约为 ~40-50 kDa。

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规格 价格 是否有货 数量
10 μg ¥1980 In-stock
50 μg ¥4890 In-stock
100 μg   询价  

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IL-22BP/IL-22RA2 Protein, Human (210a.a, HEK293, His) 相关产品:

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描述

IL-22BP/IL-22RA2 Protein, specifically Isoform 2, acts as an IL22 receptor and antagonist, inhibiting IL22 activity by preventing its interaction with the functional IL-22R complex in vitro. This regulatory role suggests its potential in modulating inflammatory responses. In contrast, Isoform 1 is involved in processes related to successful pregnancy, indicating a distinct role in reproductive physiology. The dual roles of IL-22BP isoforms highlight their versatility in influencing both inflammatory pathways and reproductive outcomes. IL-22BP/IL-22RA2 Protein, Human (210a.a, HEK293, His) is the recombinant human-derived IL-22BP/IL-22RA2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-22BP/IL-22RA2 Protein, Human (210a.a, HEK293, His) is 210 a.a., with molecular weight of ~40-50 kDa.

研究背景

IL-22BP,特别是异构体 2,充当 IL22 的受体。该亚型不仅与 IL22 结合,而且还通过阻止 IL22 与功能性 IL-22R 复合物之间的相互作用充当拮抗剂,从而在体外抑制 IL22 的活性。同工型 2 的调节功能表明其可能参与调节炎症反应。另一方面,异构体 1 涉及与建立和维持成功妊娠相关的过程,表明在生殖生理学中具有独特的作用。 IL-22BP 亚型的双重作用凸显了它们在影响炎症途径和生殖结果方面的多功能性。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q969J5-2 (T22-P231)

基因 ID
蛋白结构
N-term
IL-22BP (T22-P231)
Accession # Q969J5-2
6*His
C-term
同用名
Interleukin-22 receptor subunit alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; ZcytoR16
氨基酸序列

TQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVYFVQYKIYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP

分子量

Approximately 40-50 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

IL-22BP/IL-22RA2 Protein, Human (210a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-22BP/IL-22RA2 Protein, Human (210a.a, HEK293, His)
目录号:
HY-P72557
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