1. 重组蛋白
  2. Cytokines and Growth Factors
  3. CSF & Receptors
  4. multi-CSF/IL-3
  5. IL-3 蛋白, Mouse (HEK293, His)

IL-3 蛋白, Mouse (HEK293, His)

目录号: HY-P70685
COA 产品使用指南

IL-3 蛋白, Mouse (HEK293, His)是一种造血细胞因子,对血小板和中性粒细胞计数具有良好效果,对继发性造血功能衰竭具有治疗效果。

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规格 价格 是否有货 数量
10 μg ¥1700 In-stock
50 μg ¥5100 In-stock
100 μg   询价  
250 μg   询价  

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描述

IL-3 Protein, Mouse (HEK293, His) is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

研究背景

Interleukin-3 (IL-3) is aglycoprotein belonging to the hematopoietic growth factor family that in preclinical in vitro and in vivo studies has exhibited a multilineage activity. Recombinant human interleukin-3 (rhIL-3) enhances the mobilization of peripheral blood progenitor cells by recombinant human granulocyte colony-stimulating factor (rhG-CSF)[1]. Human interleukin-3 (hIL-3) is a multipotent hematopoietic cytokine produced by mitogen and antigen-activated keratinocytes, T-lymphocytes, mast cells, NK cells, monocytes and endothelial cells. The hematopoietic progenitor cells are proliferated and differentiated with the help of hIL-3 protein into mature erythrocytes, mast cells, megakaryocytes and granulocytes. The potential use of hIL-3 protein has been extensively tested in various clinical applications such as bone marrow transplantation, hematological malignancies, cytopenias, aplastic anemia and various types of cancer[2].

生物活性

The cell proliferation assay using NFS 60 mouse myelogenous leukemia lymphoblast cells has an ED50 value of 582 pg/mL.

种属

Mouse

表达系统

HEK293

标签

C-6*His

蛋白编号

P01586 (A27-C166)

基因 ID

16187  [NCBI]

中文名
小鼠白细胞介素-3
同用名
Interleukin-3; IL-3; Hematopoietic growth factor; Multipotential colony-stimulating factor; P-cell-stimulating factor; Il3; Il-3; Mast cell growth factor; MCGF
氨基酸序列

ASISGRDTHRLTRTLNCSSIVKEIIGKLPEPELKTDDEGPSLRNKSFRRVNLSKFVESQGEVDPEDRYVIKSNLQKLNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLNDLETVLTSRPPQPASGSVSPNRGTVEC

分子量

15-32 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

Lyophilized powder.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
参考文献

IL-3 Protein, Mouse (HEK293, His) 相关分类

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-3 Protein, Mouse (HEK293, His)
目录号:
HY-P70685
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