IL-31R alpha 蛋白, Human (HEK293, His)

IL-31R alpha Proteinas associates with IgM heavy and light chains, aiding IgM assembly and secretion. It may act as a molecular chaperone or oxidoreductase, showing low oxidoreductase activity. Isoform 2 might regulate apoptosis. IL-31R alpha contributes to peripheral B-cell function diversification by modulating Ca(2+) stores, antibody secretion, and integrin activation. Additionally, it acts as a hormone-regulated adipokine/inflammatory cytokine, involved in chronic inflammation, impacting cellular expansion and insulin response in adipocytes, potentially contributing to insulin resistance onset. IL-31R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293, with C-His labeled tag. The total length of IL-31R alpha Protein, Human (HEK293, His) is 516 a.a., with molecular weight of ~58.2 kDa.

MZB1/PERP1 与免疫球蛋白 M (IgM) 重链和轻链结合，促进 IgM 组装和分泌。它可以充当分子伴侣或氧化还原酶，因为它表现出低水平的氧化还原酶活性。此外，异构体 2 可能在细胞凋亡调节中发挥作用。MZB1/PERP1 通过调节 Ca(2+) 储存、抗体分泌和整合素激活，促进外周 B 细胞功能的多样化。此外，它作为一种激素调节的脂肪因子/促炎细胞因子，与慢性炎症有关，影响细胞扩张并减弱脂肪细胞中的胰岛素反应，可能在胰岛素抵抗的发生中发挥作用。

Human

HEK293

C-His

Q8NI17 (M1-S516)

133396  [NCBI]

Approximately 58.2 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.