IL-3R alpha/CD123 蛋白, Canine (283a.a, HEK293, His)

IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation. IL-3R alpha/CD123 Protein, Canine (283a.a, HEK293, His) is the recombinant canine-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Canine (283a.a, HEK293, His) is 283 a.a., with molecular weight of 42-50 kDa.

IL-3R α/CD123 蛋白是 I 型细胞因子受体家族的重要成员，特别归类于 5 型亚家族，强调其在介导细胞对各种细胞因子的反应中的关键作用。作为该受体家族的一部分，IL-3R α/CD123 可能与相关受体具有保守的结构和功能特征，强调了其参与特定 I 型细胞因子信号的转导。I 型细胞因子受体家族的分类强调了其在更广泛的细胞信号传导背景下的特定名称，从而深入了解其对造血和免疫调节的独特贡献。IL-3R α/CD123 的研究有助于我们了解其在生理过程中的作用，并为造血障碍和免疫失调相关疾病的治疗干预提供了潜在的应用。对 IL-3R α/CD123 作用的进一步探索有望增强我们对其对正常细胞功能和病理状况的贡献的了解。

Immobilized IL-3Rα at 1 μg/mL (100 μL/well) can bind Biotinylated IL-3 protein. The ED₅₀ for this effect is 44.84 ng/mL, corresponding to a specific activity is 2.23×10^4 Unit/mg.

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  Measured in a cell proliferation assay using A549 cells. The ED₅₀  for this effect is 3.586 ng/mL, corresponding to a specific activity is 2.79×10⁵ units/mg.

Canine

HEK293

C-6*His

XP_038305195.1 (S33-D315)

609293  [NCBI]

SEKDPDSPIKNLRMEPGSRRLTWDLSGNVSEIKCFINSKYITKAIDSRYCQFYVLPLCEVKNFTISVKQDPPFSTGLQYVPRGAEGKPAAAARGLDCWVHDVDFLTCSWEVGRAAPGDVQYRLYWRDLKAYREQECPRYEANNRGVHVRCRFDDVSRLQRHIQFWVNGTSRRSGIPCSDLCVELPEIERLSPPHITATCNKSYSMMEWKVLSHFNHRFLYELQIQKGTDPASTEKLYENHFVIYNPGNYVAKLKVQGFFRKDWSEWSAPQLFVCDPKDEHRRD

42-50 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.