IL-3R alpha/CD123 蛋白, Mouse (315a.a, HEK293, His)

IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation. Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K. This activation leads to cell proliferation and differentiation, mediated by STAT5. IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development. IL-3R alpha/CD123 Protein, Mouse (315a.a, HEK293, His) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-8*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Mouse (315a.a, HEK293, His) is 315 a.a., with molecular weight of 50-65 kDa.

IL-3R α/CD123 蛋白作为 IL3 的细胞表面受体发挥作用，并在造血祖细胞、单核细胞和 B 淋巴细胞上表达，控制造血祖细胞向谱系限制细胞的产生和分化。配体刺激后，IL-3R α 迅速与 IL3RB 发生异二聚化，导致 JAK2 和 PI3K 等效应蛋白磷酸化和激活。这些激活的蛋白质在信号细胞增殖和分化中发挥着至关重要的作用。特别是，JAK2 的激活会启动 STAT5 介导的转录程序。IL-3R α 与 IL3 相互作用，并与 α 和 β 亚基形成异二聚体，其中 β 亚基是 IL3、IL5 和 GM-CSF 受体所共有的。这些相互作用凸显了 IL-3R α 调节信号通路的复杂分子机制，有助于调节造血细胞的发育和功能。

Mouse

HEK293

C-8*His

P26952 (S17-K331)

16188  [NCBI]

SDLAAVREAPPTAVTTPIQNLHIDPAHYTLSWDPAPGADITTGAFCRKGRDIFVWADPGLARCSFQSLSLCHVTNFTVFLGKDRAVAGSIQFPPDDDGDHEAAAQDLRCWVHEGQLSCQWERGPKATGDVHYRMFWRDVRLGPAHNRECPHYHSLDVNTAGPAPHGGHEGCTLDLDTVLGSTPNSPDLVPQVTITVNGSGRAGPVPCMDNTVDLQRAEVLAPPTLTVECNGSEAHARWVARNRFHHGLLGYTLQVNQSSRSEPQEYNVSIPHFWVPNAGAISFRVKSRSEVYPRKLSSWSEAWGLVCPPEVMPVK

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.