IL1RAPL1 蛋白, Mouse (HEK293, Fc)

IL1RAPL1 protein inhibits N-type calcium channels, regulates secretion, and activates JNK signaling. It promotes neurite growth and bidirectionally induces presynaptic and postsynaptic differentiation by binding to PTPRD during dendritic spine formation. IL1RAPL1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL1RAPL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL1RAPL1 Protein, Mouse (HEK293, Fc) is 333 a.a., with molecular weight of ~85-95 kDa.

IL1RAPL1 蛋白似乎通过抑制 N 型电压门控钙通道的活性来对分泌和突触前分化进行调节控制。此外，它还可能激活 MAP 激酶 JNK，表明它在细胞内信号传导途径中具有潜在作用。此外，IL1RAPL1 与神经突生长有关，表明它参与神经元过程的延伸。值得注意的是，在树突棘形成过程中，IL1RAPL1 可以通过跨突触结合 PTPRD 双向诱导神经元突触前和突触后分化。这种多方面的功能强调了 IL1RAPL1 在调节神经元发育和突触分化的各个方面的重要性，对神经回路的形成和功能具有潜在的影响。进一步研究 IL1RAPL1 在这些过程中的具体机制和下游影响可以为其在神经发育中的作用提供有价值的见解。

Measured by its binding ability in a functional ELISA. When Recombinant Human PTPRD is immobilized at 1 µg/mL (100 µL/well) can bind Recombinant Mouse IL1RAPL1. The ED₅₀ for this effect is 20.36 ng/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Human PTPRD is immobilized at 1 µg/mL (100 µL/well) can bind Recombinant Mouse IL1RAPL1. The ED₅₀ for this effect is 20.36 ng/mL.

Mouse

HEK293

C-hFc

P59823 (R25-T357)

331461  [NCBI]

RGSADGCTDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTVQETQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYT

Approximately 85-95 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.