Integrin alpha 2B beta 3 蛋白, Human (HEK293, His)

Integrin alpha 2B beta 3 Protein, found on platelets, plays a crucial role in blood clotting. It binds to fibrinogen, facilitating platelet aggregation and forming stable clots. Understanding the functions of Integrin alpha 2B beta 3 Protein can help in developing therapies for clotting disorders and improving hemostasis. Integrin alpha 2B beta 3 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2B beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2B beta 3 Protein, Human (HEK293, His), has molecular weight of 95-115 kDa.

整合素 α-IIb/β-3 是一种多功能受体，可识别多种配体，例如纤连蛋白、纤维蛋白原、纤溶酶原、凝血酶原、血小板反应蛋白和玻连蛋白。其识别基序包括序列RGD和纤维蛋白原γ链中的特定序列HHLGGGAKQAGDV。激活后，整合素 α-IIb/β-3 通过可溶性纤维蛋白原的结合介导血小板-血小板相互作用，引发血小板快速聚集，在破裂的内皮细胞表面形成物理栓塞。这种异二聚体整联蛋白包含一个由通过二硫键连接的重链和轻链组成的 α 亚基，以及与 α-IIb 亚基结合的 β 亚基 (β-3)。整合素 α-IIb/β-3 与各种蛋白质直接相互作用，包括 RNF181、CIB1、CIB2、CIB3 和 CIB4，其中一些相互作用是钙和镁依赖性的。此外，它与 PPIA/CYPA 相互作用的方式受活性氧 (ROS)、PPIase 活性和凝血酶存在的影响。

Human

HEK293

C-His

P08514 (L32-R993)&P05106 (G27-D718)

3674  [NCBI]&3690  [NCBI]

95-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.