Integrin alpha 2B beta 3 蛋白, Mouse (HEK293, His)

Integrin alpha-IIb/beta-3, a versatile receptor recognizing various ligands, plays a pivotal role in platelet function and hemostasis. It binds fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin through the R-G-D sequence, particularly recognizing the H-H-L-G-G-G-A-K-Q-A-G-D-V sequence in fibrinogen. Activated, it facilitates platelet-platelet interactions by binding soluble fibrinogen, leading to rapid platelet aggregation. Structurally, it forms a heterodimer with the alpha subunit consisting of a heavy and a light chain linked by a disulfide bond, and the alpha-IIb subunit associates with beta-3. Its diverse interactions, including RNF181, CIB1-4, and PPIA/CYPA, underscore its integral role in orchestrating platelet responses. Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 2B beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His), has molecular weight of 90-113 kDa.

整合素 α-IIb/β-3 蛋白是一种多面受体，具有广泛的配体识别能力，包括通过 RGD 序列与纤连蛋白、纤维蛋白原、纤溶酶原、凝血酶原、血小板反应蛋白和玻连蛋白结合。具体来说，它识别纤维蛋白原 γ 链中的 HHLGGGAKQAGDV 序列。激活后，整合素 α-IIb/β-3 通过结合可溶性纤维蛋白原促进血小板-血小板相互作用，导致血小板快速聚集，在破裂的内皮细胞表面形成物理栓塞。在结构上，它形成异二聚体，其中α亚基由通过二硫键连接的重链和轻链组成，α-IIb亚基与β-3结合。此外，整合素α-IIb/β-3直接与RNF181相互作用，其细胞质尾区以钙和镁依赖性方式与CIB1、CIB2、CIB3和CIB4相互作用。此外，它与 PPIA/CYPA 的相互作用是 ROS 和 PPIase 活性依赖性的，并且在凝血酶存在时会增加。这种多样化的相互作用凸显了整合素 α-IIb/β-3 在血小板功能和止血中的不可或缺的作用。

Mouse

HEK293

C-His

Q9QUM0 (L32-R988)&O54890 (E26-D717)

16399&16416

90-113 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.