Integrin alpha V beta 6 蛋白, Human (HEK293, His-Avi)

Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Avi labeled tag. Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi), has molecular weight of 90-150 kDa.

整合素 α V beta 5 蛋白，特别是 α-V (ITGAV) 整合素亚基，可作为一系列配体的多功能受体，包括玻连蛋白、细胞趋化素、纤连蛋白、纤维蛋白原、层粘连蛋白、基质金属蛋白酶-2、骨桥蛋白、骨调节蛋白、凝血酶原、血小板反应蛋白和 vWF。ITGAV:ITGB3 识别各种配体中的 RGD 序列，与 fractalkine 结合，在 CX3CR1 依赖性 fractalkine 信号传导中充当辅助受体。此外，它还与 NRG1、FGF1、FGF2、IGF1、IGF2、IL1B、PLA2G2A、fibrillin-1 (FBN1) 和 CD40LG 形成重要的结合相互作用，从而促进多种信号通路。值得注意的是，ITGAV:ITGB3 或 ITGAV:ITGB6 复合物作为转化生长因子 β-1 (TGF-β-1) 的受体，介导其从调节性潜伏相关肽 (LAP) 中释放，并在 TGF-β1 中发挥关键作用。beta-1 激活。此外，ITGAV:ITGB5 在微生物感染期间充当 C 型腺病毒的受体。整合素 α V β 5 的整合和多功能性质强调了其在介导多种细胞反应和信号级联中的关键作用。

Measured by its binding ability in a functional ELISA. When immobilized Human ITGAV&ITGB6 at 1 μg/mL (100 μl/Well), can bind Biotinylated Human Latent TGF beta 1 and the EC₅₀ is ≤0.11 μg/mL.

Human

HEK293

C-His;C-Avi

P06756 (F31-V992)&P18564 (G22-N707)

3685  [NCBI]&3694  [NCBI]

FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPV&GCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPN

90-150 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.