Kallikrein-13 蛋白, Human (HEK293, His)

Kallikrein-13 (KLK13) is a member of KLK family and is a secreted serine protease expressed in endocrine tissues, including the prostate, testis, breast, and ovary. Expression of KLK13 is regulated by steroid hormones and may be useful as a marker for breast cancer. KLK13 is also required for the human coronavirus HKU1 infection of human respiratory epithelial cells as a priming protease. Kallikrein-13 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-13 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Kallikrein-13 Protein, Human (HEK293, His) is 246 a.a., with molecular weight of 28-38 kDa.

Kallikrein-13 (KLK13) 是 KLK 家族的成员，是一种在内分泌组织（包括前列腺、睾丸、乳腺和卵巢）中表达的分泌型丝氨酸蛋白酶。越来越多的证据表明，许多激肽释放酶与致癌作用有关，其中一些有可能成为新型癌症和其他疾病的生物标志物。KLK13 的表达受类固醇激素调节，可用作乳腺癌的标志物。KLK13 作为引发蛋白酶^[1][2]，也是人类冠状病毒 HKU1 感染人类呼吸道上皮细胞所必需的。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

Q9UKR3 (G17-I262)

26085  [NCBI]

GGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETI

28-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 10% Glycerol, pH 5.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.