2. 重组蛋白
  3. Enzymes & Regulators
  4. Oxidoreductases (EC 1)
  5. KDM3B 蛋白, Human (Myc, His-SUMO)

KDM3B 蛋白, Human (Myc, His-SUMO)

目录号: HY-P71585
产品使用指南

KDM3B蛋白是一种组蛋白去甲基化酶，主要针对组蛋白H3的“Lys-9”，催化去甲基化并产生甲醛和琥珀酸副产物。除了组蛋白修饰之外，KDM3B 还与肿瘤抑制活性有关，这表明它在细胞过程、基因表达调控和表观遗传修饰中的重要性。KDM3B 蛋白, Human (Myc, His-SUMO) 是重组的 KDM3B 蛋白，由 E. coli 表达，带有 C-Myc, N-SUMO, N-His 标签。KDM3B 蛋白, Human (Myc, His-SUMO) 全长 224 个氨基酸，分子量约为 ~45.6 kDa。

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描述

KDM3B protein is a histone demethylase that mainly targets "Lys-9" of histone H3, catalyzes demethylation and produces formaldehyde and succinic acid by-products. In addition to histone modifications, KDM3B has been implicated in tumor suppressor activity, indicating its importance in cellular processes, gene expression regulation, and epigenetic modifications. KDM3B Protein, Human (Myc, His-SUMO) is the recombinant human-derived KDM3B protein, expressed by E. coli , with C-Myc, N-SUMO, N-His labeled tag. The total length of KDM3B Protein, Human (Myc, His-SUMO) is 224 a.a., with molecular weight of ~45.6 kDa.
研究背景

KDM3B 蛋白是一种组蛋白去甲基化酶，通过特异性靶向组蛋白 H3 的“Lys-9”，在组蛋白密码中发挥着关键作用。其去甲基酶活性催化去除该残留物中的甲基，产生副产物甲醛和琥珀酸。除了参与组蛋白修饰之外，KDM3B 还表现出肿瘤抑制活性的潜力，暗示其在与基因表达和表观遗传修饰调节相关的细胞过程中的重要性。KDM3B 的特定去甲基化功能强调了其在塑造组蛋白修饰动态景观中的核心作用及其对细胞稳态和疾病的潜在影响。
种属

Human
表达系统

E. coli
标签

C-Myc;N-SUMO;N-His
蛋白编号

Q7LBC6 (1498M-1721R)
基因 ID
蛋白结构
N-term
10*His-SUMO
KDM3B (1498M-1721R)
Accession # Q7LBC6
C-term
同用名
5qNCA; C5orf7; JHDM2B; JmjC domain containing histone demethylation protein 2B; JmjC domain-containing histone demethylation protein 2B; jmjd1b; Jumonji domain containing 1B; Jumonji domain containing protein 1B; Jumonji domain-containing protein 1B; KDM3B; KDM3B_HUMAN; KIAA1082; Lysine (K) specific demethylase 3B ; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA
氨基酸序列

MPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFR

分子量

Approximately 45.6 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

KDM3B Protein, Human (Myc, His-SUMO) 相关分类

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The specific activity calculator equation

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
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