KGF-2/FGF-10 蛋白, Mouse

KGF-2/FGF-10 Protein, Mouse is a paracrine signaling molecule and is involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands.

成熟小鼠成纤维细胞生长因子-10 (FGF10) 与人和大鼠 FGF10 的氨基酸序列同一性分别为 94% 和 100%。FGF10 的促有丝分裂和趋化特性在胚胎发生过程中的许多组织中至关重要。FGF10 通过 FGF R2 (IIIb) 诱导信号传导也有助于胰腺癌的进展^[1]。FGF10 是一种旁分泌信号分子，参与肺、皮肤、耳朵和唾液腺等多个器官形态发生的分支^[2]。

Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED₅₀ this effect is <85 ng/mL, corresponding to a specific activity is >1.0 × 10⁴ units/mg.

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  Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED₅₀ this effect is 7.948 ng/mL, corresponding to a specific activity is 1.2582×10⁵ units/mg.

Mouse

E. coli

Tag Free

O35565 (S62-T209)

14165  [NCBI]

SSAGRHVRSYNHLQGDVRWRRLFSFTKYFLTIEKNGKVSGTKNEDCPYSVLEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMTIQT

Approximately 17 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 800 mM NaCl, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Nomura S, et al. FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer. Br J Cancer. 2008 Jul 22;99(2):305-13.  [Content Brief]

  [2]. Bagai S, et al. Fibroblast growth factor-10 is a mitogen for urothelial cells. J Biol Chem. 2002 Jun 28;277(26):23828-37.  [Content Brief]