1. 重组蛋白
  2. Receptor Proteins Biotinylated Proteins
  3. Killer-Cell Immunoglobulin-like Receptors
  4. KIR2DL5
  5. KIR2DL5/CD158f 蛋白, Human (HEK293, His-Avi)

KIR2DL5/CD158f 蛋白, Human (HEK293, His-Avi)

目录号: HY-P77729
COA 产品使用指南

KIR2DL5/CD158f 存在于 NK 细胞上,充当 HLA-C 等位基因的受体。其抑制功能可微调 NK 细胞活性,通过与特定的 HLA-C 分子相互作用来防止细胞裂解。这种动态参与有助于免疫系统中抑制信号的微妙平衡,调节 NK 细胞对潜在目标的反应。KIR2DL5/CD158f 蛋白, Human (HEK293, His-Avi) 是重组的 KIR2DL5/CD158f 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。KIR2DL5/CD158f 蛋白, Human (HEK293, His-Avi) 全长 219 个氨基酸,分子量为 45-52 kDa。

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20 μg ¥1060 In-stock
50 μg ¥2350 In-stock
100 μg   询价  

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描述

KIR2DL5/CD158f, present on NK cells, acts as a receptor for HLA-C alleles. Its inhibitory function finely tunes NK cell activity, preventing cell lysis by interacting with specific HLA-C molecules. This dynamic engagement contributes to the nuanced balance of inhibitory signals in the immune system, regulating NK cell responses to potential targets. KIR2DL5/CD158f Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR2DL5/CD158f protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of KIR2DL5/CD158f Protein, Human (HEK293, His-Avi) is 219 a.a., with molecular weight of 45-52 kDa.

研究背景

KIR2DL5/CD158f 在自然杀伤 (NK) 细胞上表达,充当 HLA-C 等位基因的受体。该受体以抑制方式发挥作用,调节 NK 细胞活性以防止细胞裂解。通过与特定的 HLA-C 分子相互作用,KIR2DL5 有助于免疫系统中抑制信号的微妙平衡,微调 NK 细胞对潜在目标的反应。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

Q8N109 (H22-H240)

基因 ID

57292  [NCBI]

蛋白结构
N-term
CD158f (H22-H240)
Accession # Q8N109
His-Avi
C-term
同用名
KIR2DL5A; CD158F; CD158F1; KIR2DL5; KIR2DL5.1; KIR2DL5.3; KIR2DL5A; KIR2DL5B
分子量

45-52 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE

性状

无菌粉末

组分

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

KIR2DL5/CD158f Protein, Human (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
KIR2DL5/CD158f Protein, Human (HEK293, His-Avi)
目录号:
HY-P77729
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