2. 重组蛋白
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors
  6. Killer Cell Lectin Like Receptor G1 (KLRG1)
  7. KLRG1 蛋白, Human (HEK293, His)

KLRG1 蛋白, Human (HEK293, His)

目录号: HY-P704736
产品使用指南 技术支持

KLRG1 蛋白通过与 NK 细胞和 T 细胞的非 MHC 配体结合，对 NK 细胞和 T 细胞发挥抑制作用，通过经典钙粘蛋白（如 E-钙粘蛋白/CDH1、N-钙粘蛋白/CDH2 和 R-钙粘蛋白）上的保守位点潜在地识别“缺失的自我” /CDH4。KLRG1 作为通过二硫键连接的单体和同二聚体存在，通过其 ITIM 基序与 PTPN11 和 INPP5D 相互作用，表明其参与信号转导途径。KLRG1 蛋白, Human (HEK293, His) 是重组的 KLRG1 蛋白，由 HEK293 表达，带有 N-His 标签。

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描述

KLRG1 Protein exerts inhibitory effects on NK cells and T-cells by binding to their non-MHC ligands, potentially recognizing "missing self" through conserved sites on classical cadherins like E-cadherin/CDH1, N-cadherin/CDH2, and R-cadherin/CDH4. Existing as a monomer and homodimer connected by disulfide bonds, KLRG1 interacts with PTPN11 and INPP5D via its ITIM motif, suggesting involvement in signal transduction pathways. KLRG1 Protein, Human (HEK293, His) is the recombinant human-derived KLRG1 protein, expressed by HEK293, with N-His labeled tag.
研究背景

KLRG1 蛋白通过与自然杀伤 (NK) 细胞和 T 细胞的非 MHC 配体结合，对自然杀伤 (NK) 细胞和 T 细胞的功能发挥抑制作用。它可能通过与经典钙粘蛋白上的保守位点结合来识别“缺失的自我”，专门监测靶细胞上 E-钙粘蛋白/CDH1、N-钙粘蛋白/CDH2 和 R-钙粘蛋白/CDH4 的表达。KLRG1 形成通过二硫键连接的单体和同二聚体。此外，它通过其 ITIM 基序与 PTPN11 和 INPP5D 相互作用，可能参与信号转导途径。
种属

Human
表达系统

HEK293
标签

N-His
蛋白编号

Q96E93 (L60-F195)
基因 ID

10219
蛋白结构
N-term
His
KLRG1 (L60-F195)
Accession # Q96E93
C-term
同用名
2F1 Ag; 2F1; C type lectin domain family 15 member A; C-type lectin domain family 15 member A; CLEC15A; KLRG 1; KLRG1; KLRG1 protein
预测分子量
17.4 kDa.
分子量

Approximately 30-42 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

KLRG1 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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