LIF 蛋白, Rat (HEK293, His)

Lif Protein, a cytokine, plays a vital role in cell proliferation, differentiation, and immune response regulation. Dysregulation of Lif Protein has been linked to various diseases, including cancer and inflammatory disorders. Targeting Lif Protein may offer potential therapeutic interventions in these conditions by modulating cell growth, promoting immune regulation, and suppressing inflammation. LIF Protein, Rat (HEK293, His) is the recombinant rat-derived LIF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LIF Protein, Rat (HEK293, His) is 180 a.a., with molecular weight of 30-55 kDa.

整合素 α-2/β-1，也称为 ITGA2 蛋白，作为各种细胞外基质分子的受体，包括层粘连蛋白、胶原蛋白、胶原蛋白 C 前肽、纤连蛋白和 E-钙粘蛋白。它专门识别胶原蛋白中的脯氨酸羟基化序列 GFPGER。这种整合素在介导血小板和其他细胞与胶原蛋白的粘附方面发挥着至关重要的作用。此外，它还调节胶原蛋白和胶原酶基因的表达，产生机械力，并组织新合成的细胞外基质。在微生物感染的情况下，ITGA2:ITGB1 复合物充当人类轮状病毒 A 的受体。

Measured in a cell proliferation assay using M-NFS-60 cells. The ED₅₀ for this effect is 0.2365 ng/mL, corresponding to a specific activity is 4.23×10^6 units/mg.

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  Measured in a cell proliferation assay using M-NFS-60 cells. The ED₅₀ for this effect is 0.2365 ng/mL, corresponding to a specific activity is 4.23×10⁶ units/mg.

Rat

HEK293

C-6*His

P17777-1 (S23-F202)

60584  [NCBI]

SPLPITPVNATCAIRHPCHGNLMNQIKSQLAQLNGSANALFISYYTAQGEPFPNNVDKLCAPNMTDFPPFHANGTEKTKLVELYRMVTYLGASLTNITWDQKNLNPTAVSLQIKLNATTDVMRGLLSSVLCRLCNKYHVGHVDVPCVPDNSSKEAFQRKKLGCQLLGTYKQVISVLAQAF

30-55 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.