LIV-1/SLC39A6 Protein-VLP, Human (HEK293)

LIV-1/SLC39A6 is a zinc influx transporter that regulates zinc homeostasis and induces epithelial-mesenchymal transition (EMT). Used in conjunction with SLC39A10, it can promote cellular zinc absorption and trigger EMT. LIV-1/SLC39A6 Protein-VLP, Human ((HEK293) is the recombinant human-derived LIV-1/SLC39A6 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

LIV-1/SLC39A6 是一种锌流入转运蛋白，可复杂地调节锌稳态并有助于诱导上皮间质转化 (EMT)。从功能上讲，当与 SLC39A10 形成异二聚体时，该复合物会介导细胞锌的摄取，成为 EMT 的关键触发因素。SLC39A10-SLC39A6 异二聚体不仅控制 NCAM1 磷酸化，还影响其在 EMT 过程中整合到粘着斑复合物中。这种异二聚体复合物促进的锌流入在 GSK3B 失活中发挥着至关重要的作用，导致未磷酸化 SNAI1 的核积累，随后下调 CDH1 等粘附基因，从而促进细胞粘附的丧失。除了参与 EMT 之外，SLC39A10-SLC39A6 异二聚体通过将锌导入细胞，触发最终导致有丝分裂开始的途径，在启动有丝分裂中发挥着重要作用。此外，这种转运蛋白复合物有助于 T 细胞受体信号传导调节，并促进卵母细胞到卵子转变过程中减数分裂进展的适当锌流入。

Human

HEK293

Tag Free

Q13433-1 (F29-F755)

25800

Full Lenghth of Mature Protein

Supplied as 0.2 μm filtered 溶液 of PBS, Arginine, pH7.4 with trehalose as protectant.

Solution.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.