LOX 蛋白, Human (249a.a, sf9, His, MBP)

LOX proteins play a critical role in the post-translational oxidative deamination of peptidyl lysine residues in collagen and elastin precursors, thereby shaping extracellular matrix dynamics. It regulates Ras expression, suggesting potential tumor suppressive effects, affecting cellular homeostasis and cancer-related processes. LOX Protein, Human (249a.a, sf9, His, MBP) is the recombinant human-derived LOX protein, expressed by Sf9 insect cells, with C-6*His and N-MBP labeled tag.

LOX 蛋白在纤维胶原和弹性蛋白前体中肽基赖氨酸残基的翻译后氧化脱氨基作用中发挥着关键作用，正如它参与这些结构蛋白的修饰所强调的那样。作为 Ras 表达的调节剂，LOX 还表现出对肿瘤抑制的潜在影响，表明其在细胞稳态和癌症相关过程中发挥多方面的作用。此外，该蛋白质还参与塑造主动脉壁的结构，有助于这一重要血管成分的结构完整性和功能。LOX 的多种功能强调了其在细胞外基质动力学、Ras 调节和潜在肿瘤抑制机制中的重要性，使其成为细胞和组织稳态的关键参与者。

Human

Sf9 insect cells

C-6*His;N-MBP

P28300 (D169-Y417)

4015

Full Length of Mature Protein

DDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Approximately 70-80 kDa, based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.