LRG1 蛋白, Human (HEK293, Fc-His)

Leucine-rich alpha-2-glycoprotein (encoded by LRG1) is a serum biomarkerof inflammatory bowel disease and various autoimmune diseases. LRG1 can bind to TGF-β1 (K_D: 2.32 µM) and modulate the TGFβ pathway^[1][2][3]. LRG1 Protein, Human (HEK293, Fc-His) is the recombinant human-derived LRG1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of LRG1 Protein, Human (HEK293, Fc-His) is 312 a.a., with molecular weight of 65-90 kDa.

富含亮氨酸的 α-2-糖蛋白 (由LRG1编码) 是一种约 50 kDa 的糖蛋白，是炎症性肠病和各种自身免疫性疾病的血清生物标志物。LRG1 可以与 TGF-β1 (KD: 2.32 µM) 并调节 TGFβ 通路，并通过激活成纤维细胞中的 TGF-β 信号通路促进 ECM 完整性^[1]。LRG1 通常由正在分化的中性粒细胞和肝细胞分泌^[2]。
此外，存在内皮糖蛋白的情况下，LRG1 会增强内皮细胞 TGFβ1-smad1/5/8 信号传导。LRG1 还可以促进 TGFβ1 诱导的细胞凋亡^[3]。

Human

HEK293

C-hFc;C-6*His

AAH70198.1 (V36-Q347)

116844  [NCBI]

VTLSPKDCQVFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ

65-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 200 mM NaCl, 10％ Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.