LRP-1 Cluster IV 蛋白, Human (HEK293, Fc)

LRP-1 Cluster Ⅳ protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster Ⅳ protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster Ⅳ Protein, Human (HEK293, Fc) is the recombinant human-derived LRP-1 Cluster Ⅳ protein, expressed by HEK293, with C-hFc labeled tag.

LRP-1 Cluster Ⅳ 蛋白作为多功能内吞受体出现，在凋亡细胞的内吞作用和吞噬作用中发挥关键作用。其重要性延伸至早期胚胎发育和细胞脂质稳态的基本功能。此外，LRP-1 Cluster Ⅳ 积极参与乳糜微粒残余物和激活的 LRPAP1（α2-巨球蛋白）的血浆清除，以及纤溶酶原激活剂与其内源性抑制剂之间形成的复合物的局部代谢。作为 LRPAP1 α-2-巨球蛋白受体，它进一步参与各种细胞事件，包括 TAU/MAPT 的内吞作用和随后的扩散。此外，LRP-1 Cluster Ⅳ 可以调节关键的细胞过程，例如 APP 代谢、激酶依赖性细胞内信号传导、神经元钙信号传导和神经传递。值得注意的是，在微生物感染中，该蛋白作为铜绿假单胞菌外毒素 A 的受体发挥作用，突出了其在细胞生理学和宿主-病原体相互作用中的多样化和复杂的作用。

Loaded Unconjugated Human PDGF-BB, His,Avitag on NTA Biosensor, can bind Human cluster IV Protein, Fc Tag with an affinity constant of 13.4 nM as determined in BLI assay.The bioactivity was comparable to standard batch.

Human

HEK293

C-hFc

Q07954 (S3332-D3779)

4035

Approximately 95-130 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with 10% trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.