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  3. MAGEA4 蛋白, Human (HEK293, His)

MAGEA4 蛋白, Human (HEK293, His)

目录号: HY-P700420
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MAGEA4 蛋白通过抑制 G1 期停滞来关键调节细胞增殖,并负向调节 p53 介导的细胞凋亡。它在控制关键检查点方面的作用强调了它对细胞稳态的影响,这表明它在避免异常细胞生长方面具有重要意义。MAGEA4 蛋白, Human (HEK293, His) 是重组的 MAGEA4 蛋白,由 HEK293 表达,带有 C-10*His 标签。

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描述

MAGEA4 protein critically regulates cell proliferation by inhibiting G1 phase arrest and negatively modulates p53-mediated apoptosis. Its role in controlling key checkpoints emphasizes its impact on cellular homeostasis, suggesting significance in averting aberrant cell growth. MAGEA4 Protein, Human (HEK293, His) is the recombinant human-derived MAGEA4 protein, expressed by HEK293 , with C-10*His labeled tag.

研究背景

研究证明,MAGEA4 蛋白通过抑制细胞周期停滞在 G1 期,在调节细胞增殖中发挥着至关重要的作用。此外,MAGEA4 对 p53 介导的细胞凋亡发挥负调节作用,进一步凸显其参与控制与细胞周期进程和细胞凋亡途径相关的细胞过程。这些功能强调了 MAGEA4 在调节控制细胞分裂和凋亡的关键检查点方面的重要性,表明它对细胞稳态和避免异常细胞生长的潜在影响。

种属

Human

表达系统

HEK293

标签

C-10*His

蛋白编号

P43358 (M1-V317)

基因 ID
蛋白结构
N-term
MAGEA4 (M1-V317)
Accession # P43358
10*His
C-term
蛋白长度

Full Length

中文名
MAGEA4 蛋白
同用名
MAGEA4; melanoma antigen family A, 4; MAGE4; melanoma-associated antigen 4; cancer/testis antigen family 1; member 4; CT1.4; MAGE 41; MAGE X2; MAGE4A; MAGE4B; melanoma associated antigen 4; MGC21336;
氨基酸序列

MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV

预测分子量
36.7 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

MAGEA4 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
MAGEA4 Protein, Human (HEK293, His)
目录号:
HY-P700420
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