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  2. Enzymes & Regulators
  3. Isomerases (EC 5)
  4. Maleylacetoacetate isomerase/GSTZ1 蛋白, Human (N-His)

Maleylacetoacetate isomerase/GSTZ1 蛋白, Human (N-His)

目录号: HY-P70206A
COA 产品使用指南

马来酰乙酰乙酸异构酶/GSTZ1 蛋白是 GST 超家族的成员,可对亲电子分子进行解毒。它将马来酰乙酰乙酸转化为富马酰乙酰乙酸,这是苯丙氨酸/酪氨酸降解的关键步骤。Maleylacetoacetate isomerase/GSTZ1 蛋白, Human (N-His) 是重组的 马来酰乙酰乙酸异构酶/GSTZ1 蛋白,由 E. coli 表达,带有 N-6*His 标签。Maleylacetoacetate isomerase/GSTZ1 蛋白, Human (N-His) 全长 215 个氨基酸,分子量约为 ~25 kDa。

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描述

The maleylacetoacetate isomerase/GSTZ1 protein is a member of the GST superfamily and detoxifies electrophilic molecules. It converts maleylacetoacetate to fumarylacetoacetate, a key step in phenylalanine/tyrosine degradation. Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) is the recombinant human-derived Maleylacetoacetate isomerase/GSTZ1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) is 215 a.a., with molecular weight of ~25 kDa.

研究背景

马来酰乙酰乙酸异构酶/GSTZ1 蛋白属于谷胱甘肽 S-转移酶 (GST) 超家族,编码多功能酶,通过与谷胱甘肽结合,在亲电子分子(包括致癌物、诱变剂和治疗药物)的解毒中发挥关键作用。该酶特异性催化马来酰乙酰乙酸转化为富马酰乙酰乙酸,这是苯丙氨酸/酪氨酸降解途径中的关键步骤。在小鼠中,类似基因的缺乏会导致氧化应激。该基因表现出多种编码多种蛋白质亚型的转录变体。此外,马来酰乙酰乙酸异构酶/GSTZ1 蛋白在肝脏 (RPKM 23.8)、睾丸 (RPKM 10.9) 和 24 个其他组织中广泛表达。

生物活性

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

种属

Human

表达系统

E. coli

标签

N-6*His

蛋白编号

NP_665877.1 (Q2-A216)

基因 ID
蛋白结构
N-term
6*His
GSTZ1 (Q2-A216)
Accession # NP_665877.1
C-term
同用名
rHuMaleylacetoacetate isomerase/GSTZ1, His; Maleylacetoacetate Isomerase; MAAI; GSTZ1-1; Glutathione S-Transferase Zeta 1; GSTZ1
氨基酸序列

QAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA

分子量

Approximately 25 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl,500 mM arginine, pH 7.4, 5% trehalose,5% mannitol and 0.01% Tween80.

内毒素含量

Data is not available.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For lower concentration, please reconstitute in 50mM Tris-HCL,300mM NaCl,500mM arginine,pH 7.4 buffer.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His)
目录号:
HY-P70206A
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