Matriptase/ST14 Catalytic Domain 蛋白, Human (Active)

The Matriptase/ST14 catalytic domain protein originates from epithelial cells, forms a complex with HAI-1, and is activated by sphingosine-1-phosphate. It cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen activator, suggesting its role as an activator of other proteases and potential growth factors. Matriptase/ST14 Catalytic Domain Protein, Human (Active) is the recombinant human-derived Matriptase/ST14 Catalytic Domain protein, expressed by E. coli, with tag free.

Matriptase/ST14 催化域蛋白是一种源自上皮细胞的整合膜丝氨酸蛋白酶。它与 Kunitz 型丝氨酸蛋白酶抑制剂 HAI-1 形成复合物，并被 1-磷酸鞘氨醇激活。该蛋白酶已被证明能够裂解并激活肝细胞生长因子/散射因子以及尿激酶纤溶酶原激活剂，表明其作为上皮膜上其他蛋白酶和潜在生长因子的激活剂的作用。这种蛋白酶的表达与乳腺癌、结肠癌、前列腺癌和卵巢肿瘤有关，表明它参与癌症的侵袭和转移。它在结肠 (RPKM 103.0)、小肠 (RPKM 72.7) 和 15 个其他组织中广泛表达。

Human

E. coli

Tag Free

NP_068813 (G596-V855)

6768

Approximately 27-28 kDa, based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as 0.22 μm filtered solution of 50 mM Tris, 150 mM NaCl, 10 % Trehalose, pH7.5 with glycerol as protectant.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.