MDC/CCL22 蛋白, Human (HEK293, Fc)

CCL22 (CC motif chemokine ligand 22) plays a critical role in guiding activated/effector T lymphocytes to sites of inflammation and affects various aspects of T lymphocyte physiology. It has chemotactic activity against monocytes, dendritic cells, and natural killer cells, acts as a mild chemoattractant for primary activated T lymphocytes, and acts as a potent chemoattractant for chronically activated counterparts. MDC/CCL22 Protein, Human (HEK293, Fc) is the recombinant human-derived MDC/CCL22 protein, expressed by HEK293, with C-hFc labeled tag.

CCL22（CC 基序趋化因子配体 22）在协调活化/效应 T 淋巴细胞复杂的运输模式、引导它们流向炎症部位并影响活化 T 淋巴细胞生理学的各个方面方面发挥着关键作用。CCL22 对单核细胞、树突状细胞和自然杀伤细胞具有趋化能力，可作为初级活化 T 淋巴细胞的温和趋化剂，并可作为慢性活化对应物的有效趋化剂。值得注意的是，它缺乏对中性粒细胞、嗜酸性粒细胞和静息 T 淋巴细胞的化学引诱活性。CCL22 的趋化作用是通过其与 CCR4 受体的结合介导的。有趣的是，加工形式的 MDC(3-69)、MDC(5-69) 和 MDC(7-69) 似乎没有活性，这为其在免疫细胞迁移中的调节作用增加了一层复杂性。

Human

HEK293

C-hFc

O00626 (G25-Q93)

6367

Approximately 35-40 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from 0.22 μm filtered solution of PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.