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MecA 蛋白, S. aureus (His-SUMO)

目录号: HY-P71476
产品使用指南

MecA 蛋白通过促进未折叠和聚集蛋白的识别和靶向,将其引导至 ClpC 蛋白酶或参与蛋白水解的其他蛋白,在细胞机制中发挥着至关重要的作用。该蛋白质的功能对于有效去除和降解异常蛋白质、确保细胞稳态并防止潜在有害蛋白质聚集体的积累至关重要。MecA 蛋白, S. aureus (His-SUMO) 是重组的 MecA 蛋白,由 E. coli 表达,带有 N-His, N-SUMO 标签。MecA 蛋白, S. aureus (His-SUMO) 全长 239 个氨基酸,分子量约为 ~44.3 kDa。

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描述

The MecA protein plays a crucial role in cellular machinery by facilitating the recognition and targeting of unfolded and aggregated proteins, directing them to the ClpC protease or other proteins involved in proteolysis. The function of this protein is critical for the efficient removal and degradation of abnormal proteins, ensuring cellular homeostasis and preventing the accumulation of potentially harmful protein aggregates. MecA Protein, S. aureus (His-SUMO) is the recombinant Staphylococcus aureus-derived MecA protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of MecA Protein, S. aureus (His-SUMO) is 239 a.a., with molecular weight of ~44.3 kDa.

研究背景

MecA 蛋白以其同源二聚体结构为特征,在细胞蛋白质量控制中发挥着关键作用。其主要功能涉及识别和精确靶向未折叠和聚集的蛋白质,将它们引导至 ClpC 蛋白酶或参与蛋白水解的其他蛋白质。通过其同二聚体配置,MecA 表现出与多种底物结合的非凡能力,在细胞蛋白水解网络中协调它们的有效降解。这个过程对于通过防止错误折叠或聚集的蛋白质的积累来维持细胞完整性是不可或缺的,否则可能会损害细胞功能。因此,MecA 蛋白在细胞蛋白质稳态中发挥着关键作用,确保及时去除异常蛋白以维护整体细胞健康。(

种属

Staphylococcus aureus

表达系统

E. coli

标签

N-His;N-SUMO

蛋白编号

P60186 (1M-239E)

基因 ID

/

蛋白结构
N-term
6*His-SUMO
MecA (1M-239E)
Accession # P60186
C-term
同用名
mecA; MW0880Adapter protein MecA
氨基酸序列

MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPLWIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQRTKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYYAVHFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE

分子量

Approximately 44.3 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

MecA Protein, S. aureus (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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