1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokines
  5. CCL18
  6. MIP-4/CCL18 蛋白, Human (P. pastoris, His)

MIP-4/CCL18 蛋白, Human (P. pastoris, His)

目录号: HY-P700545
产品使用指南

MIP-4/CCL18 蛋白选择性地吸引淋巴细胞,但不吸引单核细胞或粒细胞。它参与 B 细胞向淋巴结滤泡的迁移并协调免疫细胞动态。MIP-4/CCL18 蛋白, Human (P. pastoris, His) 是重组的 MIP-4/CCL18 蛋白,由 P. pastoris 表达,带有 N-6*His 标签。MIP-4/CCL18 蛋白, Human (P. pastoris, His) 全长 69 个氨基酸,分子量为 9.9 kDa。

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描述

The MIP-4/CCL18 protein selectively attracts lymphocytes, but not monocytes or granulocytes. It participates in the migration of B cells to follicles in lymph nodes and coordinates immune cell dynamics. MIP-4/CCL18 Protein, Human (P. pastoris, His) is the recombinant human-derived MIP-4/CCL18 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MIP-4/CCL18 Protein, Human (P. pastoris, His) is 69 a.a., with molecular weight of 9.9 kDa.

研究背景

MIP-4/CCL18 蛋白作为趋化因子,对淋巴细胞(不包括单核细胞或粒细胞)具有特异性亲和力。它可能参与 B 细胞迁移到淋巴结内 B 细胞滤泡的过程,这表明它在协调免疫反应的细胞动力学中发挥着作用。此外,MIP-4/CCL18 在吸引幼稚 T 淋巴细胞朝向树突状细胞和淋巴结中活化的巨噬细胞方面发挥着至关重要的作用,对各种 T 细胞亚型(包括幼稚 T 细胞、CD4+ 和 CD8+ T 细胞)表现出趋化活性。这种广泛的趋化影响使 MIP-4/CCL18 成为体液和细胞介导的免疫反应中的潜在参与者,强调了其在调节免疫细胞运输和淋巴组织内相互作用方面的多方面作用。

种属

Human

表达系统

P. pastoris

标签

N-6*His

蛋白编号

P55774 (A21-A89)

基因 ID
蛋白结构
N-term
6*His
CCL18 (A21-A89)
Accession # P55774
C-term
同用名
rHuMIP-4/CCL18; C-C motif chemokine 18; AMAC-1; SCYA18
氨基酸序列

AQVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLKLNA

分子量

9.9 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

MIP-4/CCL18 Protein, Human (P. pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
MIP-4/CCL18 Protein, Human (P. pastoris, His)
目录号:
HY-P700545
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