MMP-12 蛋白, Mouse (HEK293, His)

MMP-12 protein has significant elastolytic activity and may contribute to tissue damage and remodeling. Its substrate preferences include preference for leucine at the P1' site and aromatic/hydrophobic residues at the P1 site, and preference for small hydrophobic residues such as alanine at the P3 site. MMP-12 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-12 Protein, Mouse (HEK293, His) is 445 a.a., with molecular weight of ~64.0 kDa.

MMP-12 蛋白成为组织损伤和重塑的潜在贡献者，表现出显着的弹力分解活性。它的多功能性体现在它能够在 P1' 位点容纳大氨基酸和小氨基酸，显示出对亮氨酸的偏好。此外，MMP-12 在底物偏好方面表现出特异性，偏爱 P1 位点上的芳香族或疏水性残基，而偏爱 P3 位点上的小疏水性残基，特别是丙氨酸。这些特征强调了 MMP-12 在细胞外基质成分调节中的复杂作用，表明它参与与组织重塑和稳态相关的过程。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

C-6*His

P34960 (A29-C473)

17381  [NCBI]

APMNDSEFAEWYLSRFYDYGKDRIPMTKTKTNRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKREDVDYIFQKAFQVWSDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLYGAPVKPPSLTKPSSPPSTFCHQSLSFDAVTTVGEKIFFFKDWFFWWKLPGSPATNITSISSIWPSIPSGIQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYPRSIYSLGFSASVKKVDAAVFDPLRQKVYFFVDKHYWRYDVRQELMDPAYPKLISTHFPGIKPKIDAVLYFKRHYYIFQGAYQLEYDPLFRRVTKTLKSTSWFGC

Approximately 64.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 500 mM NaCl,0.01%Tween80, 1 mM EDTA, 50% Glycerol, pH 6.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.