MMP13 蛋白, Human (His-SUMO)

The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. MMP13 Protein, Human (His-SUMO) is the recombinant human-derived MMP13 protein, expressed by E. coli, with N-6*His and N-SUMO labeled tag.

MMP-13（基质金属蛋白酶 13）作为细胞外基质调节的关键参与者而出现，对纤维状胶原、纤连蛋白、TNC 和 ACAN 等各种蛋白质发挥影响。它在切割三螺旋胶原蛋白方面表现出显着的能力，特别是 I 型、II 型和 III 型，其中可溶性 II 型胶原蛋白的活性最高。MMP-13 的多方面作用不仅限于基质降解；它还可能作用于关键调节蛋白，包括 TGFB1 和 CCN2，从而影响伤口愈合、组织重塑、软骨降解和骨骼发育等过程。它在胚胎骨发育和骨化中不可或缺，强调了它的重要性，而它通过软骨内骨化参与骨折愈合则强调了它对生理过程的动态贡献。此外，MMP-13 在伤口愈合过程中的角质形成细胞迁移中发挥作用，并参与细胞迁移和肿瘤侵袭，反映了其对细胞功能的多种影响。

Human

E. coli

N-6*His;N-SUMO

P45452 (Y104-C471)

4322

Full Length of Mature Protein

YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC

Approximately 45-50 kDa, based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.