MTHFS 蛋白, Human (His)

MTHFS proteins play a critical role in tetrahydrofolate metabolism and help regulate carbon flow within the folate-dependent one-carbon metabolic network. This network is critical for providing the carbon units required for purine, thymidine, and amino acid biosynthesis. MTHFS Protein, Human (His) is the recombinant human-derived MTHFS protein, expressed by E. coli , with C-6*His labeled tag. The total length of MTHFS Protein, Human (His) is 203 a.a., with molecular weight of ~28.0 kDa.

MTHFS 蛋白是四氢叶酸代谢不可或缺的一部分，在叶酸依赖性一碳代谢网络内的碳流调节中发挥着关键作用。该网络对于供应关键细胞成分（包括嘌呤、胸苷和氨基酸）生物合成所需的碳至关重要。值得注意的是，MTHFS 催化 5-甲酰四氢叶酸 (5-FTHF) 不可逆转化为 5,10-次甲基四氢叶酸，这是叶酸循环中的关键步骤。这种酶活性强调了其在引导单碳单元进行各种细胞过程中的重要性。MTHFS 蛋白对维持碳中间体的平衡和可用性的贡献是细胞代谢的基础，并支持重要的生物合成途径（参考：未提供）。

Human

E. coli

C-6*His

P49914 (M1-A203)

10588  [NCBI]

MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA

Approximately 28.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.