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  4. Mucin-1/MUC1 蛋白, Human (HEK293, Fc)

Mucin-1/MUC1 蛋白, Human (HEK293, Fc)

目录号: HY-P70301
COA 产品使用指南

Mucin-1/MUC1蛋白及其α亚基具有粘附和抗粘附蛋白的双重功能,在上皮细胞上形成保护层。同时,β亚基及其C端结构域通过磷酸化和蛋白质-蛋白质相互作用参与细胞信号传导。Mucin-1/MUC1 蛋白, Human (HEK293, Fc) 是重组的 Mucin-1/MUC1 蛋白,由 HEK293 表达,带有 C-hFc 标签。Mucin-1/MUC1 蛋白, Human (HEK293, Fc) 全长 145 个氨基酸,分子量为 45-88 kDa。

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规格 价格 是否有货 数量
10 μg ¥900 In-stock
50 μg ¥2500 In-stock
100 μg   询价  

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描述

Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (HEK293, Fc) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mucin-1/MUC1 Protein, Human (HEK293, Fc) is 145 a.a., with molecular weight of 45-88 kDa.

研究背景

Mucin-1/MUC1 蛋白表现出多种功能作用:α 亚基具有细胞粘附特性,并作为粘附蛋白和抗粘附蛋白发挥作用,可能在上皮细胞上形成一层保护层,抵御细菌和酶的攻击。同时,β 亚基及其 C 末端结构域通过磷酸化和蛋白质-蛋白质相互作用参与细胞信号传导。Mucin-1/MUC1 调节 ERK、SRC 和 NF-kappa-B 通路中的信号传导,影响活化 T 细胞中的 Ras/MAPK 通路。此外,它在促进肿瘤进展、调节 TP53 介导的转录以及决定基因毒性应激反应中的细胞命运方面发挥着作用。值得注意的是,Mucin-1/MUC1 与 KLF4 结合,与 TP53 的 PE21 启动子元件结合,从而抑制 TP53 活性并促进复杂的细胞功能网络。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

P15941-11 (A23-G167)

基因 ID
蛋白结构
N-term
Mucin-1 (A23-G167)
Accession # P15941-11
hFc
C-term
同用名
rHuMucin-1, Fc; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD227; MUC1
氨基酸序列

APKPATVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPG

分子量

45-88 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

Mucin-1/MUC1 Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Mucin-1/MUC1 Protein, Human (HEK293, Fc)
目录号:
HY-P70301
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