Nectin-1 蛋白, Human (HEK293, His)

Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nectin-1 Protein, Human (HEK293, His) is 304 a.a., with molecular weight of 40-60 kDa.

Nectin-1 蛋白通过形成亲同性或异嗜性反式二聚体促进细胞与细胞的接触。已知它与 Nectin-3 和 Nectin-4 发生异嗜性相互作用。此外，这种蛋白质还具有促进神经突生长的活性。在微生物感染的情况下，Nectin-1 充当单纯疱疹病毒 1 (HHV-1)、单纯疱疹病毒 2 (HHV-2) 和伪狂犬病病毒 (PRV) 的受体。

Human

HEK293

C-6*His

Q15223 (Q31-T334)

5818  [NCBI]

QVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNIT

40-60 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.