1. 重组蛋白
  2. CD Antigens Receptor Proteins Biotinylated Proteins
  3. NK Cell CD Proteins
  4. CD337/NCR3
  5. NKp30/NCR3 蛋白, Human (HEK293, His-Avi)

NKp30/NCR3 蛋白, Human (HEK293, His-Avi)

目录号: HY-P77812
产品使用指南

NKp30/NCR3 蛋白是 NK 细胞上的细胞膜受体,通过与 BAG6 和 NCR3LG1 等配体结合而被激活。这种激活增强了 NK 细胞对产生这些配体的邻近细胞(包括肿瘤细胞)的细胞毒性。NKp30/NCR3 蛋白, Human (HEK293, His-Avi) 是重组的 NKp30/NCR3 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。NKp30/NCR3 蛋白, Human (HEK293, His-Avi) 全长 120 个氨基酸,分子量为 26-40 kDa。

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描述

NKp30/NCR3 protein is a cell membrane receptor on NK cells and is activated by binding to ligands such as BAG6 and NCR3LG1. This activation enhances NK cell cytotoxicity against neighboring cells that produce these ligands, including tumor cells. NKp30/NCR3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived NKp30/NCR3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of NKp30/NCR3 Protein, Human (HEK293, His-Avi) is 120 a.a., with molecular weight of 26-40 kDa.

研究背景

NKp30/NCR3 蛋白作为自然杀伤 (NK) 细胞的细胞膜受体,在与 BAG6 和 NCR3LG1 等细胞外配体结合后被激活。这种激活刺激 NK 细胞针对产生这些配体的邻近细胞的细胞毒性,从而控制 NK 细胞针对各种靶标(包括肿瘤细胞)的细胞毒性。BAG6 与 NCR3 的结合不仅增强了 NK 细胞介导的对未获得成熟表型的骨髓树突状细胞 (DC) 的杀伤作用,而且还诱导 NK 细胞释放 TNFA 和 IFNG。这反过来又促进骨髓树突状细胞的成熟。在未配体形式下,NKp30/NCR3 以同二聚体形式存在,并与 CD3Z、NCR3LG1 和 BAG6 相互作用,突出了其在免疫反应和 NK 细胞介导的细胞毒性中作为多方面调节剂的作用。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

O14931 (L19-T138)

基因 ID
蛋白结构
N-term
NKp30 (L19-T138)
Accession # O14931
His-Avi
C-term
同用名
CD337; LY117; NCR3; NKp30; 1C7; MALS
分子量

26-40 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

NKp30/NCR3 Protein, Human (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
NKp30/NCR3 Protein, Human (HEK293, His-Avi)
目录号:
HY-P77812
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