NKp46/NCR1 蛋白, Human (HEK293, Llama Fc)

NKp46/NCR1 protein, a cytotoxicity-activating receptor on natural killer (NK) cells, potentially enhances their efficacy in tumor cell lysis. Interacting with CD247 and FCER1G, NKp46/NCR1 plays a pivotal role in signaling pathways associated with NK cell activation and cytotoxicity. It contributes to the regulatory network for recognizing and eliminating target cells, emphasizing its importance in immune surveillance and anti-tumor responses. NKp46/NCR1 Protein, Human (HEK293, Llama Fc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293, with C-Llama Fc labeled tag.

NKp46/NCR1 蛋白作为细胞毒性激活受体，可能增强激活的自然杀伤 (NK) 细胞介导肿瘤细胞裂解的功效。该受体与 CD247 和 FCER1G 相互作用，在与 NK 细胞激活和针对靶细胞的细胞毒性相关的信号通路中发挥关键作用。NKp46/NCR1 参与激活的 NK 细胞识别和消除靶细胞的复杂调控网络，凸显了其在免疫监视和抗肿瘤反应中的重要性。

Human

HEK293

C-Llama Fc

O76036-6/AAH64806 (Q22-D254)

9437

Approximately 60-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from 0.22 μm filtered solution of Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.