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  3. NKp46/NCR1 蛋白, Human (HEK293, mFc)

NKp46/NCR1 蛋白, Human (HEK293, mFc)

目录号: HY-P78008
产品使用指南

NKp46/NCR1 蛋白是自然杀伤 (NK) 细胞上的一种细胞毒性激活受体,可能增强其裂解肿瘤细胞的功效。NKp46/NCR1 与 CD247 和 FCER1G 相互作用,在与 NK 细胞活化和细胞毒性相关的信号通路中发挥着关键作用。它有助于识别和消除靶细胞的调节网络,强调其在免疫监视和抗肿瘤反应中的重要性。NKp46/NCR1 蛋白, Human (HEK293, mFc) 是重组的 NKp46/NCR1 蛋白,由 HEK293 表达,带有 C-mFc 标签。NKp46/NCR1 蛋白, Human (HEK293, mFc) 全长 234 个氨基酸,分子量为 65-75 kDa。

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描述

NKp46/NCR1 protein, a cytotoxicity-activating receptor on natural killer (NK) cells, potentially enhances their efficacy in tumor cell lysis. Interacting with CD247 and FCER1G, NKp46/NCR1 plays a pivotal role in signaling pathways associated with NK cell activation and cytotoxicity. It contributes to the regulatory network for recognizing and eliminating target cells, emphasizing its importance in immune surveillance and anti-tumor responses. NKp46/NCR1 Protein, Human (HEK293, mFc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of NKp46/NCR1 Protein, Human (HEK293, mFc) is 234 a.a., with molecular weight of 65-75 kDa.

研究背景

NKp46/NCR1 蛋白作为细胞毒性激活受体,可能增强激活的自然杀伤 (NK) 细胞介导肿瘤细胞裂解的功效。该受体与 CD247 和 FCER1G 相互作用,在与 NK 细胞激活和针对靶细胞的细胞毒性相关的信号通路中发挥关键作用。NKp46/NCR1 参与激活的 NK 细胞识别和消除靶细胞的复杂调控网络,凸显了其在免疫监视和抗肿瘤反应中的重要性。

种属

Human

表达系统

HEK293

标签

C-mFc

蛋白编号

O76036 (Q22-N255)

基因 ID
蛋白结构
N-term
NKp46 (Q22-N255)
Accession # O76036
mFc
C-term
同用名
CD335; Ly94; NCR1; NKp46; MAR-1; NKP46FLJ99094
分子量

65-75 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

NKp46/NCR1 Protein, Human (HEK293, mFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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NKp46/NCR1 Protein, Human (HEK293, mFc)
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