NPR3 蛋白, Human (HEK293, Fc)

NPR3 Protein, a receptor for natriuretic peptides, exhibits similar affinities for NPPA/ANP, NPPB/BNP, and NPPC/CNP. It regulates diuresis, blood pressure, and skeletal development, possibly serving as a clearance receptor for NPPA, NPPB, and NPPC. Despite lacking guanylate cyclase activity, NPR3 forms disulfide-linked homodimers and interacts with OSTN, indicating potential involvement in various physiological processes. NPR3 Protein, Human (HEK293, Fc) is the recombinant human-derived NPR3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NPR3 Protein, Human (HEK293, Fc) is 458 a.a., with molecular weight of 90-100 kDa.

NPR3 蛋白作为利钠肽激素的受体，对心房利钠肽 NPPA/ANP、脑利钠肽 NPPB/BNP 和 C 型利钠肽 NPPC/CNP 表现出相似的亲和力。它参与利尿、血压和骨骼发育的调节，并可能作为 NPPA、NPPB 和 NPPC 的清除受体，从而调节它们的局部浓度和作用。尽管缺乏鸟苷酸环化酶活性，NPR3 仍形成二硫键连接的同型二聚体，并可能通过亚型 2 的 C 端半胱氨酸进行额外的二聚化。该受体还与 OSTN 相互作用，表明其可能参与多种生理过程。

Human

HEK293

C-hFc

P17342 (T24-E481)

4883  [NCBI]

TGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEE

90-100 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.