OX40 Ligand/TNFSF4 蛋白, Cynomolgus (HEK293, Fc)

The OX40 Ligand/TNFSF4 Protein, a vital member of the tumor necrosis factor family, is crucial for regulating immune responses and inflammation. Its study enhances understanding of immune modulation, offering potential applications in immunotherapy and autoimmune disease management. OX40 Ligand/TNFSF4's classification within the tumor necrosis factor family underscores its unique contributions to T cell activation and co-stimulation. Further exploration promises to enhance our knowledge of its role in both normal immune function and pathological conditions. OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293, with N-mFc labeled tag. The total length of OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is 133 a.a., with molecular weight of ~48 kDa.

OX40 配体/TNFSF4 蛋白是肿瘤坏死因子家族的重要成员，表明其在调节免疫反应和炎症过程中发挥着重要作用。作为该家族的一部分，OX40 配体/TNFSF4 可能与相关蛋白具有保守的结构和功能特征，强调其参与与免疫调节相关的信号通路。肿瘤坏死因子家族的分类强调了其在更广泛的细胞因子背景下的特定名称，从而深入了解其对 T 细胞激活和共刺激的独特贡献。OX40配体/TNFSF4的研究有助于我们了解其在免疫稳态中的作用，并在免疫治疗和自身免疫性疾病管理中提供潜在的应用。对 OX40 配体/TNFSF4 作用的进一步探索有望增强我们对其对正常免疫功能和病理状况的贡献的了解。

OX4 Ligand (human, 1 ng/mL, 7 days, added into DC-T cell cultures at days and 4) inhibits the generation of IL-1-producing T cells induced by immature DCs and DCs treated with IL-1 and IFN-α^[5].

Cynomolgus

HEK293

N-mFc

F7FL80 (Q51-L183)

706255  [NCBI]

Approximately 48 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.

• [1]. Kaur D, et al. OX40/OX40 ligand interactions in T-cell regulation and asthma. Chest. 2012 Feb;141(2):494-499.  [Content Brief]

  [2]. Fu N, et al. The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases. Front Immunol. 2021 Jun 21;12:670637.  [Content Brief]

  [3]. Croft M, et al. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev. 2009 May;229(1):173-91.  [Content Brief]

  [4]. Buglio D, et al. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood. 2011 Mar 10;117(10):2910-7  [Content Brief]

  [5]. Ito T, et al, Duramad O, Hanabuchi S, Perng OA, Gilliet M, Qin FX, Liu YJ. OX40 ligand shuts down IL-10-producing regulatory T cells. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13138-43.  [Content Brief]