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P4HB 蛋白, Mouse (HEK293, His)

目录号: HY-P74658
COA 产品使用指南

P4HB 蛋白具有多种用途和多功能,可协调细胞表面和细胞内部的二硫键催化。它表现出还原酶活性,裂解二硫键,诱导结构修饰,并作为伴侣抑制错误折叠蛋白质的聚集。P4HB 蛋白, Mouse (HEK293, His) 是重组的 P4HB 蛋白,由 HEK293 表达,带有 C-His 标签。P4HB 蛋白, Mouse (HEK293, His) 全长 490 个氨基酸,分子量为 57-70 kDa。

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10 μg ¥950 In-stock
50 μg ¥2650 In-stock
100 μg ¥4500 In-stock
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描述

P4HB proteins are versatile and multifunctional, coordinating disulfide bond catalysis at the cell surface and inside the cell. It exhibits reductase activity, cleaves disulfide bonds, induces structural modifications, and functions as a chaperone to inhibit aggregation of misfolded proteins. P4HB Protein, Mouse (HEK293, His) is the recombinant mouse-derived P4HB protein, expressed by HEK293 , with C-His labeled tag. The total length of P4HB Protein, Mouse (HEK293, His) is 490 a.a., with molecular weight of 57-70 kDa.

研究背景

P4HB 蛋白是一种多功能实体,协调二硫键形成、断裂和重排的催化作用。它位于细胞表面,具有还原酶活性,可裂解附着在细胞上的蛋白质的二硫键,并可能诱导外表面蛋白质的结构修饰。在细胞内部,P4HB 在新生蛋白质中二硫键的形成和重排中发挥作用。在升高的浓度下,并在被 FAM20C 磷酸化后,它转变为伴侣,抑制错误折叠蛋白质的聚集,而在较低的浓度下,它促进聚集,表现出抗伴侣活性。此外,P4HB 可能与其他伴侣合作,在激素生物发生过程中改变甲状腺球蛋白前体的结构。此外,它还可作为多种酶的结构亚基,包括脯氨酰 4-羟化酶和微粒体三酰甘油转移蛋白 MTTP。值得注意的是,P4HB 还充当 LGALS9 的受体,这种相互作用影响其在细胞表面的定位,增强二硫键还原酶活性,改变质膜氧化还原状态,并促进细胞迁移。

生物活性

Measured by its ability to promote aggregation of insulin in the presence of DTT. The specific activity is > 10 A650/cm/min/mg.

种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

P09103 (D20-L509)

基因 ID

18453  [NCBI]

蛋白结构
N-term
P4HB (D20-L509)
Accession # P09103
His
C-term
同用名
Protein disulfide-isomerase; PDI; ERp59; p55; P4HB; Pdia1
氨基酸序列

DALEEEDNVLVLKKSNFEEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLSDTAAAESLVDSSEVTVIGFFKDVESDSAKQFLLAAEAIDDIPFGITSNSGVFSKYQLDKDGVVLFKKFDEGRNNFEGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSSFKRAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDELTAEKITEFCHRFLEGKIKPHLMSQEVPEDWDKQPVKVLVGANFEEVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIIIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDEDLDLEEALEPDMEEDDDQKAVKDEL

分子量

57-70 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

P4HB Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
P4HB Protein, Mouse (HEK293, His)
目录号:
HY-P74658
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