PADI4 蛋白, Human (His)

PADI4 is a hydrolase that converts arginine residues in histones to citrulline. PADI4 promotes tumor progression by up-regulating the cytokine receptor CXCR2. PADI4 can also cause inflammation and immune responses. PADI4 Protein, Human (His) is the recombinant human-derived PADI4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PADI4 Protein, Human (His) is 663 a.a., with molecular weight of 71-78 kDa.

Protein-arginine deiminase type-4 是一种依赖于 Ca²⁺ 水解酶。PADI4 可以将组蛋白中的精氨酸残基转化为瓜氨酸，也可以在体内和体外将单甲基化精氨酸残基转化为瓜氨酸。PADI4 可能在粒细胞和巨噬细胞发育中起作用，导致炎症和免疫反应。PADI4 在表观遗传学中发挥作用，组蛋白 H3 和 H4 上精氨酸的去甲基化可拮抗精氨酸甲基化。PADI4 是 p53 介导的肿瘤抑制的调节因子。PADI4 通过上调细胞因子受体 CXCR2 促进肿瘤的进展。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

AAH25718.1 (M1-P663)

23569  [NCBI]

MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHSPPAKKKSTGSSTWPLDPGVEVTLTMKAASGSTGDQKVQISYYGPKTPPVKALLYLTAVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP

71-78 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 500 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.