PAK6 蛋白, Human

PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human is the recombinant human-derived PAK6 protein, expressed by E. coli , with tag free.

PAK6 是一种丝氨酸/苏氨酸蛋白激酶，作为基因转录的调节因子，其激酶活性由多种效应子触发，包括 AR 或 MAP2K6/MAPKK6。值得注意的是，它磷酸化雄激素受体/AR 的 DNA 结合域，阻碍 AR 介导的转录，并且还抑制 ESR1 介导的转录。PAK6 与 IQGAP1 的相互作用表明其参与细胞骨架调节。此外，PAK6 通过 BAD 磷酸化保护细胞免于凋亡，从而在细胞存活中发挥潜在作用。这种多方面的激酶对关键细胞过程具有调节作用，展示了其在转录控制和细胞骨架动力学中的重要性。

Human

E. coli

Tag Free

Q9NQU5 (G383-Y674)

106821730

Partial

Approximately 33.2 KDa.

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH 7.5, 500 mM NaCl, 10% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.